About phophatidylcholine specific phospholipase C


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PC-PLC specific inhibitor is D609.

Look up PC-PLC in Pubmed

1.This reagent is used with 100 microM
in this paper.

D609 inhibits the proliferation of neural progenitor cells.


2.This paper is interesting!
This paper shows with PC-PLC antibody that PC-PLC activity is there on the outer leaflet of plasma membrane!
They use 50 μg/mL D609 for 24 hour, leading to downregulation of PC-PLC activity.

Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells.