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<p><u><font color="#551A8B" size="5">SHIPについて調べた論文一覧</font></u></p>
<p> </p>
<p><a href="http://www.sciencedirect.com/science/article/pii/S0169328X99003113"><u><font color="#551A8B" size="5">Localization of mRNA for SHIP2, SH2 domain-containing inositol
polyphosphate 5-phosphatase, in the brain of developing and mature
rats</font></u></a></p>
<p> </p>
<div class="titleline_focus">
<div id="focusButton" class="nojs" style="text-align:right;float:right;margin-left:20px;">
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<div id="artiHead" class="artiHead" style="padding-bottom:0px;padding-left:0px;padding-right:0px;padding-top:0px;">
<a id="ddJrnl" href="http://www.sciencedirect.com/science/journal/0169328X"><b><font color="#0156AA">Molecular Brain
Research</font></b></a><br /><a href="http://www.sciencedirect.com/science?_ob=PublicationURL&_hubEid=1-s2.0-S0169328X00X00745&_cid=271021&_pubType=JL&view=c&_auth=y&_acct=C000008318&_version=1&_urlVersion=0&_userid=107951&md5=293834daa3b0ccbfaf9e8b0340fc6ed4">
<font color="#0156AA">Volume 75, Issue 1</font></a>, 10 January 2000, Pages
172-177</div>
<hr class="titleline_focus_hr" size="1" /></div>
<p><a href="http://www.sciencedirect.com/science/article/pii/S0169328X99003113">http://www.sciencedirect.com/science/article/pii/S0169328X99003113</a></p>
<p>comment: this paper shows that the expression signal was evident in cell of
the white matters, presumptive<span class="nbApiHighlight">oligodendrocytes</span>, and no significant expression was
seen in<span class="nbApiHighlight">neurons</span>throughout the
development.</p>
<p> </p>
<div class="cit"><a title="Journal of immunology (Baltimore, Md. : 1950)." href="http://www.ncbi.nlm.nih.gov/pubmed?term=ship1%20inhibition%20increases%20immunoregulatory#">
<u><font color="#333333">J Immunol.</font></u></a>2010 Apr 1;184(7):3582-9.
Epub 2010 Mar 3.</div>
<h1><span class="highlight">SHIP1</span><span class="highlight">inhibition</span><span class="highlight">increases</span><span class="highlight">immunoregulatory</span>capacity and triggers apoptosis of
hematopoietic cancer cells.</h1>
<div class="auths"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Brooks%20R%22%5BAuthor%5D"><u><font color="#333333">
Brooks R</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Fuhler%20GM%22%5BAuthor%5D"><u><font color="#333333">Fuhler
GM</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Iyer%20S%22%5BAuthor%5D"><u><font color="#333333">Iyer
S</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Smith%20MJ%22%5BAuthor%5D"><u><font color="#333333">Smith
MJ</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Park%20MY%22%5BAuthor%5D"><u><font color="#333333">Park
MY</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Paraiso%20KH%22%5BAuthor%5D"><u><font color="#333333">Paraiso
KH</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Engelman%20RW%22%5BAuthor%5D"><u><font color="#333333">Engelman
RW</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kerr%20WG%22%5BAuthor%5D"><u><font color="#333333">Kerr
WG</font></u></a>.</div>
<p> </p>
<p> </p>
<h1 id="article-title-1"><span style="font-size:smaller;">The Inositol
Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in
Neuroprotection and Memory Function in Mouse Brain</span></h1>
<p><span class="slug-ahead-of-print-date">September 9, 2010</span></p>
<p> </p>
<p> </p>
<p><span class="slug-ahead-of-print-date">Aoki K, Nakamura T, Inoue T, Meyer T,
and Matsuda M.<br />
An essential role for the SHIP2-dependent negative feedback loop in
neuritogenesis of NGF-stimulated PC12 cells.<br /><b>J.Cell Biol. </b>2007 Jun 4;177(5):817-27</span></p>
<p><u><font color="#551A8B" size="5">SHIPについて調べた論文一覧</font></u></p>
<p>SHIPを調べての印象。</p>
<p>基本的にSHIPは免疫細胞で研究が進んでおり、PTENに比べて、脳においてはそれほど研究されていない。</p>
<p>ただ、PC12細胞において、SHIP2が軸索成長に関与していること。</p>
<p>また、SHIP2の発現量増加が、LTPに正に働くこと。</p>
<p>が報告されている。</p>
<p>ただ、一方で、SHIP2のmRNAは脳の神経細胞には発現していないという報告もある。</p>
<p>SHIP1については、さらに報告が少ない。SHIP2の阻害剤があることが判明した。</p>
<p>また、SHIP2についても、最近開発されているがどこで、売っているかは不明。 </p>
<p> </p>
<p> </p>
<p> </p>
<p><a href="http://www.sciencedirect.com/science/article/pii/S0169328X99003113"><u><font color="#551A8B" size="5">Localization of mRNA for SHIP2, SH2 domain-containing inositol
polyphosphate 5-phosphatase, in the brain of developing and mature
rats</font></u></a></p>
<p> </p>
<div class="titleline_focus">
<div id="focusButton" class="nojs" style="text-align:right;float:right;margin-left:20px;">
<div class="focusOn"> </div>
<div class="focusOff"> </div>
</div>
<div id="artiHead" class="artiHead" style="padding-bottom:0px;padding-left:0px;padding-right:0px;padding-top:0px;">
<a id="ddJrnl" href="http://www.sciencedirect.com/science/journal/0169328X"><b><font color="#0156AA">Molecular Brain
Research</font></b></a><br /><a href="http://www.sciencedirect.com/science?_ob=PublicationURL&_hubEid=1-s2.0-S0169328X00X00745&_cid=271021&_pubType=JL&view=c&_auth=y&_acct=C000008318&_version=1&_urlVersion=0&_userid=107951&md5=293834daa3b0ccbfaf9e8b0340fc6ed4">
<font color="#0156AA">Volume 75, Issue 1</font></a>, 10 January 2000, Pages
172-177</div>
<hr class="titleline_focus_hr" size="1" /></div>
<p><a href="http://www.sciencedirect.com/science/article/pii/S0169328X99003113">http://www.sciencedirect.com/science/article/pii/S0169328X99003113</a></p>
<p>comment: this paper shows that the expression signal was evident in cell of
the white matters, presumptive<span class="nbApiHighlight">oligodendrocytes</span>, and no significant expression was
seen in<span class="nbApiHighlight">neurons</span>throughout the
development.</p>
<p> </p>
<div class="cit"><a title="Journal of immunology (Baltimore, Md. : 1950)." href="http://www.ncbi.nlm.nih.gov/pubmed?term=ship1%20inhibition%20increases%20immunoregulatory#">
<u><font color="#333333">J Immunol.</font></u></a>2010 Apr 1;184(7):3582-9.
Epub 2010 Mar 3.</div>
<h1><span class="highlight">SHIP1</span><span class="highlight">inhibition</span><span class="highlight">increases</span><span class="highlight">immunoregulatory</span>capacity and triggers apoptosis of
hematopoietic cancer cells.</h1>
<div class="auths"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Brooks%20R%22%5BAuthor%5D"><u><font color="#333333">
Brooks R</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Fuhler%20GM%22%5BAuthor%5D"><u><font color="#333333">Fuhler
GM</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Iyer%20S%22%5BAuthor%5D"><u><font color="#333333">Iyer
S</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Smith%20MJ%22%5BAuthor%5D"><u><font color="#333333">Smith
MJ</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Park%20MY%22%5BAuthor%5D"><u><font color="#333333">Park
MY</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Paraiso%20KH%22%5BAuthor%5D"><u><font color="#333333">Paraiso
KH</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Engelman%20RW%22%5BAuthor%5D"><u><font color="#333333">Engelman
RW</font></u></a>,<a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kerr%20WG%22%5BAuthor%5D"><u><font color="#333333">Kerr
WG</font></u></a>.</div>
<p> </p>
<p> </p>
<h1 id="article-title-1"><span style="font-size:smaller;">The Inositol
Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in
Neuroprotection and Memory Function in Mouse Brain</span></h1>
<p><span class="slug-ahead-of-print-date">September 9, 2010</span></p>
<p> </p>
<p> </p>
<p><span class="slug-ahead-of-print-date">Aoki K, Nakamura T, Inoue T, Meyer T,
and Matsuda M.<br />
An essential role for the SHIP2-dependent negative feedback loop in
neuritogenesis of NGF-stimulated PC12 cells.<br /><b>J.Cell Biol. </b>2007 Jun 4;177(5):817-27</span></p>
