About phophatidylcholine specific phospholipase C

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About phophatidylcholine specific phospholipase C」(2010/07/02 (金) 19:59:12) の最新版変更点

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PC-PLC specific inhibitor is D609. Look up PC-PLC in Pubmed 1.This reagent is used with 100 microM in this paper. D609 inhibits the proliferation of neural progenitor cells. [[D609-01>http://www.ncbi.nlm.nih.gov/pubmed/20568314]] 2.This paper is interesting! This paper shows with PC-PLC antibody that PC-PLC activity is there on the outer leaflet of plasma membrane! They use 50 μg/mL D609 for 24 hour, leading to downregulation of PC-PLC activity. Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells.
PC-PLC specific inhibitor is D609. Look up PC-PLC in Pubmed 1.This reagent is used with 100 microM in this paper. D609 inhibits the proliferation of neural progenitor cells. [[D609-01>http://www.ncbi.nlm.nih.gov/pubmed/20568314]] 2.This paper is interesting! This paper shows with PC-PLC antibody that PC-PLC activity is there on the outer leaflet of plasma membrane! They use 50 μg/mL D609 for 24 hour, leading to downregulation of PC-PLC activity. Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells. [[D609-02>http://breast-cancer-research.com/content/12/3/R27]]

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